INMUNIZACIÓN CON PÉPTIDOS NEURALES MODIFICADOS COMO ESTRATEGIA TERAPÉUTICA EN LESIÓN DE MÉDULA ESPINAL

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Andrea Ibarra García
Raúl Silva García
Antonio Ibarra

Resumen

El uso de péptidos neurales para el tratamiento de lesiones de médula espinal.

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Ibarra García, A., Silva García, R., & Ibarra, A. (2023). INMUNIZACIÓN CON PÉPTIDOS NEURALES MODIFICADOS COMO ESTRATEGIA TERAPÉUTICA EN LESIÓN DE MÉDULA ESPINAL. +Ciencia, (31), 31–40. Recuperado a partir de https://revistas.anahuac.mx/index.php/masciencia/article/view/1558
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Referencias

Devivo MJ. Epidemiology of traumatic spinal cord injury: trends and future implications. Spinal Cord 2012;

: 365-372.

Yuying Chen, MD National Spinal Cord Injury Model

Systems Database. National Spinal Cord Injury Statistical Center. 1970. https://www.nscisc.uab.edu/ (consultado el 11 de 2022).

Censo de Población y Vivienda 2020. Información de

México, Discapacidad. INEGI. 2020. https://cuentame.inegi.org.mx/poblacion/discapacidad.aspx (consultado el 28 de noviembre de 2022).

Ahuja CS, Wilson JR, Nori S, Kotter MRN, Druschel C,

Curt A et al. Traumatic spinal cord injury. Nat Rev Dis

Primers 2017; 3: 17018.

Quadri SA, Farooqui M, Ikram A, Zafar A, Khan MA, Suriya SS et al. Recent update on basic mechanisms of

spinal cord injury. Neurosurg Rev 2020; 43: 425-441.

Hauben E, Nevo U, Yoles E, Moalem G, Agranov E,

Mor F et al. Autoimmune T cells as potential neuroprotective therapy for spinal cord injury. Lancet 2000;

: 286-287.

Rodríguez-Barrera R, Flores-Romero A, García E,

Fernández-Presas AM, Incontri-Abraham D, NavarroTorres L et al. Immunization with neural-derived peptides increases neurogenesis in rats with chronic spinal

cord injury. CNS Neurosci Ther 2020; 26: 650-658.

Dumont RJ, Okonkwo DO, Verma S, Hurlbert RJ, Boulos PT, Ellegala DB et al. Acute spinal cord injury, part I:

pathophysiologic mechanisms. Clin Neuropharmacol

; 24: 254-264.

Alizadeh A, Dyck SM, Karimi-Abdolrezaee S. Traumatic spinal cord injury: An overview of pathophysiology,

models and acute injury mechanisms. Front Neurol

; 10: 282.

Venkatesh K, Ghosh SK, Mullick M, Manivasagam G,

Sen D. Spinal cord injury: pathophysiology, treatment

strategies, associated challenges, and future implications. Cell Tissue Res 2019; 377: 125-151.

Tator CH. Update on the pathophysiology and pathology

of acute spinal cord injury. Brain Pathol 1995; 5: 407-413.

Cuzzocrea S, Riley DP, Caputi AP, Salvemini D. Antioxidant therapy: a new pharmacological approach in

shock, inflammation, and ischemia/reperfusion injury.

Pharmacol Rev 2001; 53: 135-159.

Hall ED, Andrus PK, Yonkers PA, Smith SL, Zhang JR,

Taylor BM et al. Generation and detection of hydroxyl

radical following experimental head injury. Ann N Y

Acad Sci 1994; 738: 15-24.

Farooque M, Hillered L, Holtz A, Olsson Y. Effects of

moderate hypothermia on extracellular lactic acid and

amino acids after severe compression injury of rat spinal cord. J Neurotrauma 1997; 14: 63-69.

Goldshmit Y, Banyas E, Bens N, Yakovchuk A, Ruban

A. Blood glutamate scavengers and exercises as an

effective neuroprotective treatment in mice with spinal

cord injury. J Neurosurg Spine 2020; 33: 692-704.

Park E, Velumian AA, Fehlings MG. The role of excitotoxicity in secondary mechanisms of spinal cord

injury: a review with an emphasis on the implications

for white matter degeneration. J Neurotrauma 2004;

: 754-774.

Springer JE, Azbill RD, Knapp PE. Activation of the

caspase-3 apoptotic cascade in traumatic spinal cord

injury. Nat Med 1999; 5: 943-946.

Dusart I, Schwab ME. Secondary cell death and the

inflammatory reaction after dorsal hemisection of the

rat spinal cord. Eur J Neurosci 1994; 6: 712-724.

Beck KD, Nguyen HX, Galvan MD, Salazar DL, Woodruff TM, Anderson AJ. Quantitative analysis of cellular

inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment. Brain 2010; 133: 433-447.

Carlson SL, Parrish ME, Springer JE, Doty K, Dossett L. Acute inflammatory response in spinal cord

following impact injury. Exp Neurol 1998; 151: 77-88.

Wu F, Ding X-Y, Li X-H, Gong M-J, An J-Q, Lai J-H et

al. Cellular inflammatory response of the spleen after

acute spinal cord injury in rat. Inflammation 2019; 42:

-1640.

Guizar-Sahagun G, Grijalva I, Madrazo I, Franco-Bourland R, Salgado H, Ibarra A et al. Development of posttraumatic cysts in the spinal cord of rats-subjected to

severe spinal cord contusion. Surg Neurol 1994; 41:

-249.

Popovich PG, Wei P, Stokes BT. Cellular inflammatory

response after spinal cord injury in Sprague-Dawley

and Lewis rats. J Comp Neurol 1997; 377: 443-464.

Gensel JC, Zhang B. Macrophage activation and its

role in repair and pathology after spinal cord injury.

Brain Res 2015; 1619: 1-11.

Ibarra A, Correa D, Willms K, Merchant MT, GuizarSahagún G, Grijalva I et al. Effects of cyclosporin-A

on immune response, tissue protection and motor

function of rats subjected to spinal cord injury. Brain

Res 2003; 979: 165-178.

Butovsky O, Hauben E, Schwartz M. Morphological

aspects of spinal cord autoimmune neuroprotection: colocalization of T cells with B7--2 (CD86) and prevention of cyst formation. FASEB J 2001; 15: 1065–1067.

Jones TB. Lymphocytes and autoimmunity after spinal cord injury. Exp Neurol 2014; 258: 78-90.

Moalem G, Gdalyahu A, Shani Y, Otten U, Lazarovici P,

Cohen IR et al. Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity. J Autoimmun 2000; 15: 331-345.

Barouch R, Schwartz M. Autoreactive T cells induce

neurotrophin production by immune and neural cells

in injured rat optic nerve: implications for protective

autoimmunity. FASEB J 2002; 16: 1304-1306.

Ibarra A, García E, Flores N, Martiñón S, Reyes R,

Campos MG et al. Immunization with neural-derived

antigens inhibits lipid peroxidation after spinal cord injury. Neurosci Lett 2010; 476: 62-65.

Rodríguez-Barrera R, Fernández-Presas AM, García

E, Flores-Romero A, Martiñón S, González-Puertos

VY et al. Immunization with a neural-derived peptide

protects the spinal cord from apoptosis after traumatic

injury. Biomed Res Int 2013; 2013: 827517.

Bethea JR, Castro M, Keane RW, Lee TT, Dietrich WD,

Yezierski RP. Traumatic spinal cord injury induces nuclear factor-kappaB activation. J Neurosci 1998; 18:

-3260.

Raposo C, Graubardt N, Cohen M, Eitan C, London

A, Berkutzki T et al. CNS repair requires both effector

and regulatory T cells with distinct temporal and spatial profiles. J Neurosci 2014; 34: 10141-10155.

Lee K-H, Yun S-J, Nam KN, Gho YS, Lee EH. Activation of microglial cells by ceruloplasmin. Brain Res

; 1171: 1-8.

Li L, Lu J, Tay SSW, Moochhala SM, He BP. The

function of microglia, either neuroprotection or neurotoxicity, is determined by the equilibrium among factors released from activated microglia in vitro. Brain

Res 2007; 1159: 8-17.

Tang Y, Le W. Differential roles of M1 and M2 microglia

in neurodegenerative diseases. Mol Neurobiol 2016;

: 1181-1194.

Li J, Yu S, Lu X, Cui K, Tang X, Xu Y et al. The phase

changes of M1/M2 phenotype of microglia/macrophage following oxygen-induced retinopathy in mice. Inflamm Res 2021; 70: 183-192.

Shaked I, Porat Z, Gersner R, Kipnis J, Schwartz M.

Early activation of microglia as antigen-presenting

cells correlates with T cell-mediated protection and

repair of the injured central nervous system. J Neuroimmunol 2004; 146: 84-93.

Franciosi S, Choi HB, Kim SU, McLarnon JG. IL-8

enhancement of amyloid-beta (Abeta 1-42)-induced

expression and production of pro-inflammatory cytokines and COX-2 in cultured human microglia. J Neuroimmunol 2005; 159: 66-74.

Fan B, Wei Z, Yao X, Shi G, Cheng X, Zhou X et al.

Microenvironment imbalance of spinal cord injury. Cell

Transplant 2018; 27: 853-866.

Vanegas H, Schaible HG. Prostaglandins and

cyclooxygenases [correction of cycloxygenases] in

the spinal cord. Prog Neurobiol 2001; 64: 327-363.

López-Vales R, García-Alías G, Guzmán-Lenis MS,

Forés J, Casas C, Navarro X et al. Effects of COX-2

and iNOS inhibitors alone or in combination with olfactory ensheathing cell grafts after spinal cord injury.

Spine (Phila Pa 1976) 2006; 31: 1100-1106.

Kroner A, Rosas Almanza J. Role of microglia in spinal cord injury. Neurosci Lett 2019; 709: 134370.

Schwartz M. Sell Memorial Lecture. Helping the body

to cure itself: immune modulation by therapeutic vaccination for spinal cord injury. J Spinal Cord Med 2003;

Suppl 1: S6-10.

Schwartz M, Kipnis J. Self and non-self discrimination

is needed for the existence rather than deletion of autoimmunity: the role of regulatory T cells in protective

autoimmunity. Cell Mol Life Sci 2004; 61: 2285-2289.

Shaked I, Tchoresh D, Gersner R, Meiri G, Mordechai S, Xiao X et al. Protective autoimmunity:

interferon-gamma enables microglia to remove glutamate without evoking inflammatory mediators: IFNα-activated microglia benefits neurons. J Neurochem

; 92: 997-1009.

Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE,

Pluchino S et al. Microglia activated by IL-4 or IFNgamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol

Cell Neurosci 2006; 31: 149-160.

Hauben E, Butovsky O, Nevo U, Yoles E, Moalem G,

Agranov E et al. Passive or active immunization with

myelin basic protein promotes recovery from spinal

cord contusion. J Neurosci 2000; 20: 6421-6430.

Kipnis J, Yoles E, Schori H, Hauben E, Shaked I,

Schwartz M. Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response. J Neurosci 2001; 21: 4564-4571.

Yoles E, Hauben E, Palgi O, Agranov E, Gothilf A, Cohen A et al. Protective autoimmunity is a physiological

response to CNS trauma. J Neurosci 2001; 21: 3740-

Nel AE, Slaughter N. T-cell activation through the antigen receptor. Part 2: role of signaling cascades in Tcell differentiation, anergy, immune senescence, and

development of immunotherapy. J Allergy Clin Immunol 2002; 109: 901-915.

Hauben E, Schwartz M. Therapeutic vaccination

for spinal cord injury: helping the body to cure itself.

Trends Pharmacol Sci 2003; 24: 7-12.

Gaur A, Boehme SA, Chalmers D, Crowe PD, Pahuja

A, Ling N et al. Amelioration of relapsing experimental

autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms. J Neuroimmunol 1997; 74: 149-158.

Ibarra A, Hauben E, Butovsky O, Schwartz M. The therapeutic window after spinal cord injury can accommodate T cell-based vaccination and methylprednisolone in rats. Eur J Neurosci 2004; 19: 2984-2990.

Martiñon S, García E, Flores N, Gonzalez I, Ortega T,

Buenrostro M et al. Vaccination with a neural-derived

peptide plus administration of glutathione improves

the performance of paraplegic rats: Improvement of

protective autoimmunity. Eur J Neurosci 2007; 26:

-412.

Hauben E, Gothilf A, Cohen A, Butovsky O, Nevo U,

Smirnov I et al. Vaccination with dendritic cells pulsed with peptides of myelin basic protein promotes

functional recovery from spinal cord injury. J Neurosci

; 23: 8808-8819.

García E, Silva-García R, Mestre H, Flores N, Martiñón

S, Calderón-Aranda ES et al. Immunization with A91

peptide or copolymer-1 reduces the production of nitric oxide and inducible nitric oxide synthase gene expression after spinal cord injury. J Neurosci Res 2012;

: 656-663.

Martiñón S, García-Vences E, Toscano-Tejeida D,

Flores-Romero A, Rodriguez-Barrera R, Ferrusquia M

et al. Long-term production of BDNF and NT-3 induced by A91-immunization after spinal cord injury. BMC

Neurosci 2016; 17: 42.

García E, Silva-García R, Flores-Romero A, BlancasEspinoza L, Rodríguez-Barrera R, Ibarra A. The severity of spinal cord injury determines the inflammatory gene expression pattern after immunization with

neural-derived peptides. J Mol Neurosci 2018; 65:

-195.

Rodríguez-Barrera R, Flores-Romero A, FernándezPresas AM, García-Vences E, Silva-García R, Konigsberg M et al. Immunization with neural derived

peptides plus scar removal induces a permissive microenvironment, and improves locomotor recovery after chronic spinal cord injury. BMC Neurosci 2017; 18.

https://doi.org/10.1186/s12868-016-0331-2

Martiñón S, García E, Gutierrez-Ospina G, Mestre H,

Ibarra A. Development of protective autoimmunity by

immunization with a neural-derived peptide is ineffective in severe spinal cord injury. PLoS One 2012; 7:

e32027.

Santoscoy C, Ríos C, Franco-Bourland RE, Hong E,

Bravo G, Rojas G et al. Lipid peroxidation by nitric oxide supplements after spinal cord injury: effect of antioxidants in rats. Neurosci Lett 2002; 330: 94-98.

Guízar-Sahagún G, Ibarra A, Espitia A, Martínez A,

Madrazo I, Franco-Bourland RE. Glutathione monoethyl ester improves functional recovery, enhances

neuron survival, and stabilizes spinal cord blood flow

after spinal cord injury in rats. Neuroscience 2005;

: 639-649.

Dröge W, Schulze-Osthoff K, Mihm S, Galter D,

Schenk H, Eck HP et al. Functions of glutathione and

glutathione disulfide in immunology and immunopathology. FASEB J 1994; 8: 1131-1138.

García E, Rodríguez-Barrera R, Buzoianu-Anguiano V,

Flores-Romero A, Malagón-Axotla E, Guerrero-Godinez M et al. Use of a combination strategy to improve

neuroprotection and neuroregeneration in a rat model

of acute spinal cord injury. Neural Regen Res 2019;

: 1060-1068.

Parra-Villamar D, Blancas-Espinoza L, Garcia-Vences

E, Herrera-García J, Flores-Romero A, Toscano-Zapien A et al. Neuroprotective effect of immunomodulatory peptides in rats with traumatic spinal cord injury.

Neural Regen Res 2021