Bioethical reflections on advanced oral cavity cancer in oral and maxillofacial surgery. Systematic review
Main Article Content
Abstract
Advanced oral cavity cancer is the most common oncological pathology among head and neck tumors for maxillofacial surgeons. That is why, as the disease progresses, a whole series of complex situations can arise, ranging from severe complications to a possible fatal outcome. This review sought to identify and analyze these situations, which are presented as dilemmas that must be addressed through informed and reasoned reflection. This poses a significant challenge for today’s maxillofacial surgeons, who must understand bioethics as a scientific and humanistic discipline that is essential for reflecting on and responding appropriately to these situations. The enormous scientific and technical development of the specialty cannot be ignored when it comes to the care that must be provided to cancer patients, especially in the face of the possibility of abandonment, futility, and therapeutic obstinacy. On the contrary, it must be a guarantee that the vulnerability of the patient will be cared for and protected at all times. This requires the acquisition of new skills that allow us to integrate all the useful elements that ensure respect for the dignity and quality of life of the person.
Downloads
Article Details
Section

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Medicina y Ética is distributed under a Creative Commons License Atribución-NoComercial-CompartirIgual 4.0 Internacional.
The author keeps the property rights with no restriction whatsoever and guarantees the magazine the right to be the first publication of the work. The author is free to deposit the published version in any other medium, such as an institutional archive or on his own website.
How to Cite
References
1. Mateo-Sidrón Antón M, Somacarrera Pérez M. Cáncer oral: genética, prevención, diagnóstico y tratamiento. revisión de la literatura. Av Odontoestomatol. 2015; 31(4): 247-259. https://dx.doi.org/10.4321/S0213-12852015000400002
2. Tirelli G, Gatto A, Boscolo Nata F, Bussani R, Piccinato A, Marcuzzo A, Tofanelli M. Prognosis of oral cancer: a comparison of the staging systems given in the 7th and 8th editions of the American Joint Committee on Cancer Staging Manual. Br J Oral Maxillofac Surg. 2018; 56(1):8-13. https://doi.org/10.1016/j.bjoms.2017.11.009
3. Gangopadhyay A, Bhatt S, Nandy K, Rai S, Rathod P, Puj KS. Survival Impact of Surgical Resection in Locally Advanced T4b Oral Squamous Cell Carcinoma. Laryngoscope. 2021; 131(7): E2266-E2274. https://doi.org/10.1002/lary.29394
4. Lacas B, Bourhis J, Overgaard J, Zhang Q, Grégoire V, Nankivell. Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis. Lancet Oncol. 2017; 18(9):1221-1237. https://doi.org/10.1016/S1470-2045(17)30458-8
5. Gallegos-Hernández J, Abrego-Vázquez J. Tratamiento del cáncer avanzado de cabeza y cuello. ¿Neoadyuvancia, concomitancia o cirugía? Cirugía y cirujanos. 2021; 89(1), 1-3. https://doi.org/10.24875/ciru.19001705
6. Schwartz P, Sachs G. Rethinking Decision Quality: Measures, Meaning, and Bioethics. Hastings Cent Rep. 2022; 52(6):13-22. https://doi.org/10.1002/hast.1443
7. Conley J. Ethics in head and neck surgery. Arch Otolaryngol. 1981; 107(11):655-7. https://doi.org/10.1001/archotol.1981.00790470003002
8. Hermerén G. The principle of proportionality revisited: interpretations and applications. Med Health Care Philos. 2012; 15(4):373-82. https://doi.org/10.1007/s11019-011-9360-x
9. Gómez-Sancho M, Altisent R, Bátiz J, Ciprés L, Corral P, González-Fernández J. Atención médica al final de la vida: Conceptos. Rev. Soc. Esp. Dolor. 2010; 17(3): 177-179. http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S113480462010000300007&lng=es
10. Ramos Pozón, S. Bioética: una reflexión necesaria para las decisiones que más importan, Plataforma Editorial, Barcelona; 2018.
11. Altisent R. Temas de ética clínica para estudiantes de medicina, Digital Reasons, Madrid; 2025.
12. Beauchamp T, Childress J. Principios de ética biomédica, Masson, Barcelona; 1989.
13. Page M, McKenzie J, Bossuyt P, Boutron I, Hoffmann T, Mulrow C. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021; 29;372: n71.
14. Page M, Moher D, Bossuyt P, Boutron I, Hoffmann TC, Mulrow C. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 2021; 29;372: n160.
15. Almadori G, Rigante M, Bussu F, Parrilla C, Gallus R, Barone Adesi L. Impact of microvascular free flap reconstruction in oral cavity cancer: our experience in 130 cases. Acta Otorhinolaryngol. 2015; 35(6):386-93. https://doi.org/10.14639/0392-100X-919
16. Barata P, Cardoso A, Custodio M, Alves M, Papoila A, António B, Lawlor PG. Symptom clusters and survival in Portuguese patients with advanced cancer. Cancer Med. 2016; 5(10):2731-2739. https://doi.org/10.1002/cam4.860
17. Belloni E, Tentoni S, Cella A, Cassinelli D, Bertè R, Scagnelli P. Radiological examinations on end-stage oncologic patients before hospice admission. Radiol Med. 2017; 122(10):793-797. https://doi.org/10.1007/s11547-017-0776-0
18. Boceta J, Boceta J, De la Torre A, Samper D, Farto M, Sánchez-de la Rosa R. Consensus and controversies in the definition, assessment, treatment and monitoring of BTcP: results of a Delphi study. Clin Transl Oncol. 2016; 18(11):10881097. https://doi.org/10.1007/s12094-016-1490-4
19. Bossi P, Di Pede P, Guglielmo M, Granata R, Alfieri S, Iacovelli NA. Prevalence of Fatigue in Head and Neck Cancer Survivors. Ann Otol Rhinol Laryngol. 2019; 128(5):413-419. https://doi.org/10.1177/0003489419826138
20. Carta F, Quartu D, Mariani C, Tatti M, Marrosu V, Gioia E, Gerosa C, Zanda JSA, Chuchueva N, Figus A, Puxeddu R. Compartmental Surgery With Microvascular Free Flap Reconstruction in Patients With T1-T4 Squamous Cell Carcinoma of the Tongue: Analysis of Risk Factors, and Prognostic Value of the 8th Edition AJCC TNM Staging System. Front Oncol. 2020; 14; 10:984. https://doi.org/10.3389/fonc.2020.00984
21. Chen Y, Yen J, Chen W, Chen I, Lai C, Lu C, Song D. Preoperative Computed Tomography Angiography for Evaluation of Feasibility of Free Flaps in Difficult Reconstruction of Head and Neck. Ann Plast Surg. 2016; 76 Suppl 1: S19-24. 10.1097/SAP.0000000000000690. https://doi.org/10.1097/SAP.0000000000000690
22. Hasegawa T, Yatagai N, Furukawa T, Wakui E, Saito I, Takeda D. The prospective evaluation and risk factors of dysphagia after surgery in patients with oral cancer. J Otolaryngol Head Neck Surg. 2021; 25;50(1):4. https://doi.org/10.1186/s40463-020-00479-6
23. Hsiang C, Chen A, Chen C, Chen M. Early Postoperative Oral Exercise Improves Swallowing Function Among Patients with Oral Cavity Cancer: A Randomized Controlled Trial. Ear Nose Throat J. 2019; 98(6): E73-E80. https://doi.org/10.1177/0145561319839822
24. Kannan B, Jayaseelan VP, Arumugam P. Immunotherapy for oral cancer treatment through targeting of IDO1 and its pathway. J Stomatol Oral Maxillofac Surg. 2023; 124(1S):101375. https://doi.org/10.1016/j.jormas.2022.101375
25. Machiels JP, Tao Y, Licitra L, Burtness B, Tahara M, Rischin D. KEYNOTE-412 Investigators. Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomized, double-blind, phase 3 trial. Lancet Oncol. 2024; 25(5):572-587. https://doi.org/10.1016/S1470-2045(24)00100-1
26. Nakayama Y, Yamakawa N, Ueyama Y, Yagyuu T, Ueda N, Nakagawa Y. Examination of Suprahyoid Muscle Resection and Other Factors Affecting Swallowing Function in Patients With Advanced Oral Cancer After Surgical Resection and Reconstruction. J Craniofac Surg. 2022; 33(8):e840-e844. https://doi.org/10.1097/SCS.0000000000008770
27. Nocon C, Ajmani G, Bhayani M. Association of Facility Volume With Positive Margin Rate in the Surgical Treatment of Head and Neck Cancer. JAMA Otolaryngol Head Neck Surg. 2018; 144(12):1090-1097. https://doi.org/10.1001/jamaoto.2018.2421
28. Nuchit S, Lam-Ubol A, Paemuang W, Talungchit S, Chokchaitam O, Mungkung O, Pongcharoen T, Trachootham D. Alleviation of dry mouth by saliva substitutes improved swallowing ability and clinical nutritional status of post-radiotherapy head and neck cancer patients: a randomized controlled trial. Support Care Cancer. 2020; 28(6):2817-2828. https://doi.org/10.1007/s00520-019-05132-1
29. Okano W, Hayashi R, Matsuura K, Shinozaki T, Tomioka T. Extent of salvage neck dissection following chemoradiation for locally advanced head and neck cancer. Head Neck. 2021; 43(2):413-418. https://doi.org/10.1002/hed.26494
30. Patil V, Noronha V, Menon N, Rai R, Bhattacharjee A, Singh A. Low-Dose Immunotherapy in Head and Neck Cancer: A Randomized Study. J Clin Oncol. 2023; 41(2):222-232. https://doi.org/10.1200/JCO.22.01015
31. Pedrini Cruz R. Death with dignity: Are we providing adequate palliative care to cancer patients? Eur J Cancer Care. 2022; 31(6): e13512. https://doi.org/10.1111/ecc.13512
32. Pyszora A, Budzyński J, Wójcik A, Prokop A, Krajnik M. Physiotherapy program reduces fatigue in patients with advanced cancer receiving palliative care: randomized controlled trial. Support Care Cancer. 2017; 25(9):2899-2908. https://doi.org/10.1007/s00520-017-3742-4
33. Roberts MK, Fisher DM, Parker LE, Darnell D, Sugarman J, Carrithers J, et al. Ethical and Regulatory Concerns in Pragmatic Clinical Trial Monitoring and Oversight. Ethics Hum Res. 2020; 42(5):29-37. https://doi.org/10.1002/eahr.500066
34. Rosenberg A, Bradford M, McCauley E, Curtis J, Wolfe J, Baker K, Yi-Frazier JP. Promoting resilience in adolescents and young adults with cancer: Results from the PRISM randomized controlled trial. Cancer. 2018; 124(19):3909-3917. https://doi.org/10.1002/cncr.31666
35. Warnakulasuriya S, Kerr AR. Oral Cancer Screening: Past, Present, and Future. J Dent Res. 2021; 100(12):1313-1320. https://doi.org/10.1177/00220345211014795
36. Wang L, Dong Q, Ye M, Du J, Zhou R, Cai X. Effect of Different Repair and Reconstruction Methods Combined with Psychological Intervention on Quality of Life and Negative Emotion in Patients with Oral Cancer. Comput Math Methods Med. 2022; 2022:7359584. https://doi.org/10.1155/2022/7359584
37. Varkey B. Principles of Clinical Ethics and Their Application to Practice. Med Princ Pract. 2021; 30(1):17-28. https://doi.org/10.1159/000509119
38. Jonas, H. El principio de responsabilidad: ensayo de una ética para la civilización tecnológica. Círculo de Lectores, Madrid; 1994.
39. Pérez-Soba Díez del Corral J. Bioethics of principles. Cuad Bioet. 2008; 19(65):43-55.
40. Byers P. Dependence and a Kantian conception of dignity as a value. Theor Med Bioeth. 2016; 37(1):61-9. https://doi.org/10.1007/s11017-016-9351-2
41. Gracia D. Morir con dignidad: Dilemas éticos en el final de la vida. Doce Calles Fundación de Ciencias de la Salud, Madrid; 1995.
42. Tonelli M, Sullivan M. Person-centered shared decision making. J Eval Clin Pract. 2019; 25(6):1057-1062. https://doi.org/10.1111/jep.13260
43. Ubbink D, Hageman M, Legemate D. Shared Decision-Making in Surgery. Surg Technol Int. 2015; 26:31-6.
44. Shin J. Conflicts of Interest in Research and Clinical Practice. J Korean Soc Radiol. 2022; 83(4):771-775. https://doi.org/10.3348/jksr.2022.0050
45. Denholm L, Lal A, Henderson M, McConnell P. Bioethics: canceling patient operations. Curr Opin Anaesthesiol. 2020; 33(2):211-217. https://doi.org/10.1097/ACO.0000000000000828
46. Prescher H, Gudex LM, Mauch JT, Vercler CJ. Avoiding Patient Abandonment: A Pathway to Ethical Resolution in Situations of Untenable Patient-Surgeon Relationships. Plast Reconstr Surg. 2025; 155(2):391-396. https://doi.org/10.1097/PRS.0000000000011735
47. López E. Ética y vida: desafíos actuales. San Pablo, Madrid; 1990.
48. Little J. Ethics in surgical practice. Br J Surg. 2001; 88(6):769-70. https://doi.org/10.1046/j.0007-1323.2001.01791.x
49. Little J. Guest commentary: is there a distinctively surgical ethics? Surgery. 2001; 129(6):668-71. https://doi.org/10.1067/msy.2001.111213
50. Pellegrini C. Presidential address: The surgeon of the future: anchoring innovation and science with moral values. Bull Am Coll Surg. 2013; 98(12):8-14.
51. López M. El cuidado un imperativo para la bioética. Servicio de Publicaciones Universidad Pontificia de Comillas, Madrid; 2011.
52. Baena C. Limitation of therapeutic effort: When less is more. Colomb Med (Cali). 2015; 46(1):1-2.
53. García R, Real de Asúa D, García L, Herreros B. Do internists know what limitation of therapeutic effort means? Rev Clin Esp. 2021; 221(5):274-278. https://doi.org/10.1016/j.rce.2020.01.005
54. Ferreres A. Ethics and Surgery in the 21(st) century. Cir Esp. 2015; 93(6):357-8. https://doi.org/10.1016/j.ciresp.2014.12.002
55. Meert AP, Berghmans T, Hardy M, Markiewicz E, Sculier JP. Non-invasive ventilation for cancer patients with life-support techniques limitation. Support Care Cancer. 2006; 14(2):167-71. https://doi.org/10.1007/s00520-005-0845-0
56. Bosman J, Bood Z, Scherer-Rath M. The effects of art therapy on anxiety, depression, and quality of life in adults with cancer: a systematic literature review. Supportive Care in Cancer. 2021 ;29(5):2289-2298.
57. Vanbutsele G, Pardon K, Van Belle S, Surmont V, De Laat M, Colman R. Effect of early and systematic integration of palliative care in patients with advanced cancer: a randomized controlled trial. Lancet Oncol. 2018; 19(3):394-404. https://doi.org/10.1016/S1470-2045(18)30060-3
58. Emanuel E, Emanuel LL. Cuatro modelos de la relación médico paciente. Triacastela, Madrid; 1999.
59. Sanz Á, Del Valle M, Flores L. Bioethical issues of the Covid-19 pandemic in Spain. A systematic review. Cuad Bioet. 2024; 35(114):125-141. https://doi.org/10.30444/CB.169
60. García J. Personalist bioethics and principialist bioethics. Perspectives. Cuad Bioet. 2013; 24(80):67-76.