Reflexiones desde la bioética sobre el cáncer de cavidad oral avanzado en cirugía oral y maxilofacial. Revisión sistemática

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El cáncer de cavidad oral avanzado es la patología oncológica más frecuente dentro de los tumores de cabeza y cuello para el cirujano  maxilofacial. Es por ello por lo que, en el devenir de la enfermedad, pueden aparecer toda una serie de situaciones complejas, que van desde severas complicaciones hasta un posible desenlace fatal. En esta revisión, se trató de identificar y analizar estas situaciones, que se plantean en forma de dilemas, que deben ser atendidos desde una reflexión fundamentada y razonada. Esto supone un importante reto para el cirujano maxilofacial actual, que debe entender la bioética como una disciplina científica y humanística, esencial para reflexionar y responder de forma adecuada a estas situaciones. El enorme desarrollo científico y técnico de la especialidad, no puede ser ajeno a la atención que debe brindarse al paciente oncológico, especialmente ante la posibilidad de abandono, futilidad y obstinación terapéutica. Por el contrario, debe ser una garantía de que la vulnerabilidad del enfermo será atendida y protegida en todo momento. Esto requiere de la adquisición de nuevas habilidades que nos permitan integrar todos los elementos útiles que aseguren el respeto a la dignidad y calidad de vida de la persona.

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Reflexiones desde la bioética sobre el cáncer de cavidad oral avanzado en cirugía oral y maxilofacial. Revisión sistemática. (2025). Medicina Y Ética, 36(4), 1374-1420. https://doi.org/10.36105/mye.2025v36n4.04

Referencias

1. Mateo-Sidrón Antón M, Somacarrera Pérez M. Cáncer oral: genética, prevención, diagnóstico y tratamiento. revisión de la literatura. Av Odontoestomatol. 2015; 31(4): 247-259. https://dx.doi.org/10.4321/S0213-12852015000400002

2. Tirelli G, Gatto A, Boscolo Nata F, Bussani R, Piccinato A, Marcuzzo A, Tofanelli M. Prognosis of oral cancer: a comparison of the staging systems given in the 7th and 8th editions of the American Joint Committee on Cancer Staging Manual. Br J Oral Maxillofac Surg. 2018; 56(1):8-13. https://doi.org/10.1016/j.bjoms.2017.11.009

3. Gangopadhyay A, Bhatt S, Nandy K, Rai S, Rathod P, Puj KS. Survival Impact of Surgical Resection in Locally Advanced T4b Oral Squamous Cell Carcinoma. Laryngoscope. 2021; 131(7): E2266-E2274. https://doi.org/10.1002/lary.29394

4. Lacas B, Bourhis J, Overgaard J, Zhang Q, Grégoire V, Nankivell. Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis. Lancet Oncol. 2017; 18(9):1221-1237. https://doi.org/10.1016/S1470-2045(17)30458-8

5. Gallegos-Hernández J, Abrego-Vázquez J. Tratamiento del cáncer avanzado de cabeza y cuello. ¿Neoadyuvancia, concomitancia o cirugía? Cirugía y cirujanos. 2021; 89(1), 1-3. https://doi.org/10.24875/ciru.19001705

6. Schwartz P, Sachs G. Rethinking Decision Quality: Measures, Meaning, and Bioethics. Hastings Cent Rep. 2022; 52(6):13-22. https://doi.org/10.1002/hast.1443

7. Conley J. Ethics in head and neck surgery. Arch Otolaryngol. 1981; 107(11):655-7. https://doi.org/10.1001/archotol.1981.00790470003002

8. Hermerén G. The principle of proportionality revisited: interpretations and applications. Med Health Care Philos. 2012; 15(4):373-82. https://doi.org/10.1007/s11019-011-9360-x

9. Gómez-Sancho M, Altisent R, Bátiz J, Ciprés L, Corral P, González-Fernández J. Atención médica al final de la vida: Conceptos. Rev. Soc. Esp. Dolor. 2010; 17(3): 177-179. http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S113480462010000300007&lng=es

10. Ramos Pozón, S. Bioética: una reflexión necesaria para las decisiones que más importan, Plataforma Editorial, Barcelona; 2018.

11. Altisent R. Temas de ética clínica para estudiantes de medicina, Digital Reasons, Madrid; 2025.

12. Beauchamp T, Childress J. Principios de ética biomédica, Masson, Barcelona; 1989.

13. Page M, McKenzie J, Bossuyt P, Boutron I, Hoffmann T, Mulrow C. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021; 29;372: n71.

14. Page M, Moher D, Bossuyt P, Boutron I, Hoffmann TC, Mulrow C. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 2021; 29;372: n160.

15. Almadori G, Rigante M, Bussu F, Parrilla C, Gallus R, Barone Adesi L. Impact of microvascular free flap reconstruction in oral cavity cancer: our experience in 130 cases. Acta Otorhinolaryngol. 2015; 35(6):386-93. https://doi.org/10.14639/0392-100X-919

16. Barata P, Cardoso A, Custodio M, Alves M, Papoila A, António B, Lawlor PG. Symptom clusters and survival in Portuguese patients with advanced cancer. Cancer Med. 2016; 5(10):2731-2739. https://doi.org/10.1002/cam4.860

17. Belloni E, Tentoni S, Cella A, Cassinelli D, Bertè R, Scagnelli P. Radiological examinations on end-stage oncologic patients before hospice admission. Radiol Med. 2017; 122(10):793-797. https://doi.org/10.1007/s11547-017-0776-0

18. Boceta J, Boceta J, De la Torre A, Samper D, Farto M, Sánchez-de la Rosa R. Consensus and controversies in the definition, assessment, treatment and monitoring of BTcP: results of a Delphi study. Clin Transl Oncol. 2016; 18(11):10881097. https://doi.org/10.1007/s12094-016-1490-4

19. Bossi P, Di Pede P, Guglielmo M, Granata R, Alfieri S, Iacovelli NA. Prevalence of Fatigue in Head and Neck Cancer Survivors. Ann Otol Rhinol Laryngol. 2019; 128(5):413-419. https://doi.org/10.1177/0003489419826138

20. Carta F, Quartu D, Mariani C, Tatti M, Marrosu V, Gioia E, Gerosa C, Zanda JSA, Chuchueva N, Figus A, Puxeddu R. Compartmental Surgery With Microvascular Free Flap Reconstruction in Patients With T1-T4 Squamous Cell Carcinoma of the Tongue: Analysis of Risk Factors, and Prognostic Value of the 8th Edition AJCC TNM Staging System. Front Oncol. 2020; 14; 10:984. https://doi.org/10.3389/fonc.2020.00984

21. Chen Y, Yen J, Chen W, Chen I, Lai C, Lu C, Song D. Preoperative Computed Tomography Angiography for Evaluation of Feasibility of Free Flaps in Difficult Reconstruction of Head and Neck. Ann Plast Surg. 2016; 76 Suppl 1: S19-24. 10.1097/SAP.0000000000000690. https://doi.org/10.1097/SAP.0000000000000690

22. Hasegawa T, Yatagai N, Furukawa T, Wakui E, Saito I, Takeda D. The prospective evaluation and risk factors of dysphagia after surgery in patients with oral cancer. J Otolaryngol Head Neck Surg. 2021; 25;50(1):4. https://doi.org/10.1186/s40463-020-00479-6

23. Hsiang C, Chen A, Chen C, Chen M. Early Postoperative Oral Exercise Improves Swallowing Function Among Patients with Oral Cavity Cancer: A Randomized Controlled Trial. Ear Nose Throat J. 2019; 98(6): E73-E80. https://doi.org/10.1177/0145561319839822

24. Kannan B, Jayaseelan VP, Arumugam P. Immunotherapy for oral cancer treatment through targeting of IDO1 and its pathway. J Stomatol Oral Maxillofac Surg. 2023; 124(1S):101375. https://doi.org/10.1016/j.jormas.2022.101375

25. Machiels JP, Tao Y, Licitra L, Burtness B, Tahara M, Rischin D. KEYNOTE-412 Investigators. Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomized, double-blind, phase 3 trial. Lancet Oncol. 2024; 25(5):572-587. https://doi.org/10.1016/S1470-2045(24)00100-1

26. Nakayama Y, Yamakawa N, Ueyama Y, Yagyuu T, Ueda N, Nakagawa Y. Examination of Suprahyoid Muscle Resection and Other Factors Affecting Swallowing Function in Patients With Advanced Oral Cancer After Surgical Resection and Reconstruction. J Craniofac Surg. 2022; 33(8):e840-e844. https://doi.org/10.1097/SCS.0000000000008770

27. Nocon C, Ajmani G, Bhayani M. Association of Facility Volume With Positive Margin Rate in the Surgical Treatment of Head and Neck Cancer. JAMA Otolaryngol Head Neck Surg. 2018; 144(12):1090-1097. https://doi.org/10.1001/jamaoto.2018.2421

28. Nuchit S, Lam-Ubol A, Paemuang W, Talungchit S, Chokchaitam O, Mungkung O, Pongcharoen T, Trachootham D. Alleviation of dry mouth by saliva substitutes improved swallowing ability and clinical nutritional status of post-radiotherapy head and neck cancer patients: a randomized controlled trial. Support Care Cancer. 2020; 28(6):2817-2828. https://doi.org/10.1007/s00520-019-05132-1

29. Okano W, Hayashi R, Matsuura K, Shinozaki T, Tomioka T. Extent of salvage neck dissection following chemoradiation for locally advanced head and neck cancer. Head Neck. 2021; 43(2):413-418. https://doi.org/10.1002/hed.26494

30. Patil V, Noronha V, Menon N, Rai R, Bhattacharjee A, Singh A. Low-Dose Immunotherapy in Head and Neck Cancer: A Randomized Study. J Clin Oncol. 2023; 41(2):222-232. https://doi.org/10.1200/JCO.22.01015

31. Pedrini Cruz R. Death with dignity: Are we providing adequate palliative care to cancer patients? Eur J Cancer Care. 2022; 31(6): e13512. https://doi.org/10.1111/ecc.13512

32. Pyszora A, Budzyński J, Wójcik A, Prokop A, Krajnik M. Physiotherapy program reduces fatigue in patients with advanced cancer receiving palliative care: randomized controlled trial. Support Care Cancer. 2017; 25(9):2899-2908. https://doi.org/10.1007/s00520-017-3742-4

33. Roberts MK, Fisher DM, Parker LE, Darnell D, Sugarman J, Carrithers J, et al. Ethical and Regulatory Concerns in Pragmatic Clinical Trial Monitoring and Oversight. Ethics Hum Res. 2020; 42(5):29-37. https://doi.org/10.1002/eahr.500066

34. Rosenberg A, Bradford M, McCauley E, Curtis J, Wolfe J, Baker K, Yi-Frazier JP. Promoting resilience in adolescents and young adults with cancer: Results from the PRISM randomized controlled trial. Cancer. 2018; 124(19):3909-3917. https://doi.org/10.1002/cncr.31666

35. Warnakulasuriya S, Kerr AR. Oral Cancer Screening: Past, Present, and Future. J Dent Res. 2021; 100(12):1313-1320. https://doi.org/10.1177/00220345211014795

36. Wang L, Dong Q, Ye M, Du J, Zhou R, Cai X. Effect of Different Repair and Reconstruction Methods Combined with Psychological Intervention on Quality of Life and Negative Emotion in Patients with Oral Cancer. Comput Math Methods Med. 2022; 2022:7359584. https://doi.org/10.1155/2022/7359584

37. Varkey B. Principles of Clinical Ethics and Their Application to Practice. Med Princ Pract. 2021; 30(1):17-28. https://doi.org/10.1159/000509119

38. Jonas, H. El principio de responsabilidad: ensayo de una ética para la civilización tecnológica. Círculo de Lectores, Madrid; 1994.

39. Pérez-Soba Díez del Corral J. Bioethics of principles. Cuad Bioet. 2008; 19(65):43-55.

40. Byers P. Dependence and a Kantian conception of dignity as a value. Theor Med Bioeth. 2016; 37(1):61-9. https://doi.org/10.1007/s11017-016-9351-2

41. Gracia D. Morir con dignidad: Dilemas éticos en el final de la vida. Doce Calles Fundación de Ciencias de la Salud, Madrid; 1995.

42. Tonelli M, Sullivan M. Person-centered shared decision making. J Eval Clin Pract. 2019; 25(6):1057-1062. https://doi.org/10.1111/jep.13260

43. Ubbink D, Hageman M, Legemate D. Shared Decision-Making in Surgery. Surg Technol Int. 2015; 26:31-6.

44. Shin J. Conflicts of Interest in Research and Clinical Practice. J Korean Soc Radiol. 2022; 83(4):771-775. https://doi.org/10.3348/jksr.2022.0050

45. Denholm L, Lal A, Henderson M, McConnell P. Bioethics: canceling patient operations. Curr Opin Anaesthesiol. 2020; 33(2):211-217. https://doi.org/10.1097/ACO.0000000000000828

46. Prescher H, Gudex LM, Mauch JT, Vercler CJ. Avoiding Patient Abandonment: A Pathway to Ethical Resolution in Situations of Untenable Patient-Surgeon Relationships. Plast Reconstr Surg. 2025; 155(2):391-396. https://doi.org/10.1097/PRS.0000000000011735

47. López E. Ética y vida: desafíos actuales. San Pablo, Madrid; 1990.

48. Little J. Ethics in surgical practice. Br J Surg. 2001; 88(6):769-70. https://doi.org/10.1046/j.0007-1323.2001.01791.x

49. Little J. Guest commentary: is there a distinctively surgical ethics? Surgery. 2001; 129(6):668-71. https://doi.org/10.1067/msy.2001.111213

50. Pellegrini C. Presidential address: The surgeon of the future: anchoring innovation and science with moral values. Bull Am Coll Surg. 2013; 98(12):8-14.

51. López M. El cuidado un imperativo para la bioética. Servicio de Publicaciones Universidad Pontificia de Comillas, Madrid; 2011.

52. Baena C. Limitation of therapeutic effort: When less is more. Colomb Med (Cali). 2015; 46(1):1-2.

53. García R, Real de Asúa D, García L, Herreros B. Do internists know what limitation of therapeutic effort means? Rev Clin Esp. 2021; 221(5):274-278. https://doi.org/10.1016/j.rce.2020.01.005

54. Ferreres A. Ethics and Surgery in the 21(st) century. Cir Esp. 2015; 93(6):357-8. https://doi.org/10.1016/j.ciresp.2014.12.002

55. Meert AP, Berghmans T, Hardy M, Markiewicz E, Sculier JP. Non-invasive ventilation for cancer patients with life-support techniques limitation. Support Care Cancer. 2006; 14(2):167-71. https://doi.org/10.1007/s00520-005-0845-0

56. Bosman J, Bood Z, Scherer-Rath M. The effects of art therapy on anxiety, depression, and quality of life in adults with cancer: a systematic literature review. Supportive Care in Cancer. 2021 ;29(5):2289-2298.

57. Vanbutsele G, Pardon K, Van Belle S, Surmont V, De Laat M, Colman R. Effect of early and systematic integration of palliative care in patients with advanced cancer: a randomized controlled trial. Lancet Oncol. 2018; 19(3):394-404. https://doi.org/10.1016/S1470-2045(18)30060-3

58. Emanuel E, Emanuel LL. Cuatro modelos de la relación médico paciente. Triacastela, Madrid; 1999.

59. Sanz Á, Del Valle M, Flores L. Bioethical issues of the Covid-19 pandemic in Spain. A systematic review. Cuad Bioet. 2024; 35(114):125-141. https://doi.org/10.30444/CB.169

60. García J. Personalist bioethics and principialist bioethics. Perspectives. Cuad Bioet. 2013; 24(80):67-76.