Effect of treatment with probiotics in the reduction of altered levels of the lipid profile in humans and rats: a systematic review

Autores/as

  • Arturo Martínez Colón Universidad Anáhuac México, Facultad de Ciencias de la Salud, Estado de México https://orcid.org/0009-0004-3240-4162
  • Marcos Meneses Mayo Universidad Anáhuac México, Facultad de Ciencias de la Salud, Estado de México
  • Leticia Lillo Ahuacatitan Universidad Anáhuac México, Facultad de Ciencias de la Salud, Estado de México https://orcid.org/0009-0001-3387-6071

DOI:

https://doi.org/10.36105/psrua.2023v3n6.02

Palabras clave:

probióticos, hipolipemiante, niños, adultos, ratas, perfil de lípidos

Resumen

Introducción: Las evidencias sugieren que el uso de probióticos puede prevenir o ayudar en el tratamiento de enfermedades como la obesidad, diarrea aguda infecciosa, síndrome de intestino irritable, problemas hepáticos y la corrección de la hiperlipidemia ya sea del colesterol total, HD-CL, LDL-C o triglicéridos. Se han estudiado cepas probióticas que con diversos mecanismos pueden disminuir los niveles lipídicos en niños, adultos y ratas.  Objetivo: Evidenciar el efecto hipolipemiante de algunas cepas probióticas probadas en humanos y ratas, recopilando investigaciones que lo avalen. Métodos: Se realizó una búsqueda de artículos con año de publicación entre 2013 a 2023, estudios experimentales, observacionales y de cohortes publicados en inglés, texto completo disponible y análisis de la disminución de algún marcador del perfil de lípidos por el uso de probióticos. Los términos MESH y los operadores booleanos utilizados para la búsqueda fueron “probióticos, hipolipemiante, niños; adultos; ratas y perfil de lípidos”. Fuentes de datos: las bases de datos utilizadas fueron PubMed, Google Scholar, Elsevier, Clinical Key y ScienceDirect. Resultados: De 2150 artículos, 30 fueron incluidos. Después del análisis de los artículos seleccionados, los resultados revelan que los probióticos tienen un efecto benéfico sobre el perfil de lípidos en un 25,01%. Se redujo 16,65% el nivel de colesterol total, 32,02% LDL-C y elevando el HDL-C un 21,71%. Conclusión: La suplementación con cepas específicas de probióticos tiene efecto hipolipemiante, en especial es reductor de la hipercolesterolemia a través de diversos mecanismos, pero se requieren más estudios para determinar la dosificación y el tiempo de tratamiento.

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2023-12-31

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Martínez Colón, A. ., Meneses Mayo, M. ., & Lillo Ahuacatitan, L. . (2023). Effect of treatment with probiotics in the reduction of altered levels of the lipid profile in humans and rats: a systematic review. Proceedings of Scientific Research Universidad Anáhuac. Multidisciplinary Journal of Healthcare, 3(6), 14–31. https://doi.org/10.36105/psrua.2023v3n6.02