COVID-19 host-genetics: Known and novel variants in an admixed population

Autores/as

  • Vanessa Gonzalez-Covarrubiasa Instituto Nacional de Medicina Genómica (INMEGEN), CDMX, México. https://orcid.org/0000-0003-2072-2847
  • José Luis Cruz-Jaramilllo Código 46, Laboratorio de Genotipificación, Cuernavaca Morelos, México.
  • Willebaldo García‐Muñoz Código 46, Laboratorio de Genotipificación, Cuernavaca Morelos, México
  • Lourdes Anzures-Cortés Código 46, Laboratorio de Genotipificación, Cuernavaca Morelos, México
  • Lorenza Haddad-Talancón Código 46, Laboratorio de Genotipificación, Cuernavaca Morelos, México https://orcid.org/0000-0002-8747-9186
  • Sergio Sánchez-García Centro Médico Nacional Siglo XXI, Instituto Nacional del Seguro Social (IMSS), Unidad de Investigación Epidemiológica y en Servicios de Salud, Área Envejecimiento, CDMX, México
  • María del Carmen Jiménez Martínez Unidad Periférica “Conde de Valenciana”-UNAM, Facultad de Medicina, Departamento de Bioquímica, Departamento de Inmunología, CDMX, México
  • Edgar Pérez Barragáne Hospital General de Zona no. 48, IMSS, CDMX, México
  • David Koepsell Texas A&M, College Station, Texas, United States. https://orcid.org/0000-0001-7250-8928
  • Alejandro Nieto-Patlán Texas Children's Hospital, Center for Human Immunobiology, Department of Allergy, Immunology and Rheumatology, Houston, TX, United States
  • José Darío Martínez-Ezquerro Centro Médico Nacional Siglo XXI, Instituto Nacional del Seguro Social (IMSS), Unidad de Investigación Epidemiológica y en Servicios de Salud, Área Envejecimiento, CDMX, México https://orcid.org/0000-0002-2609-4207
  • Kenneth Rubio-Carrascoa Universidad Nacional Autónoma de México (UNAM), Facultad de Química, CDMX, México https://orcid.org/0000-0002-0601-3051
  • Nancy Vara Gama Universidad Nacional Autónoma de México (UNAM), Facultad de Química, CDMX, México
  • Laura del Bosque-Plata Instituto Nacional de Medicina Genómica (INMEGEN), CDMX, México
  • Mauricio Rodríguez-Dorantes Instituto Nacional de Medicina Genómica (INMEGEN), CDMX, México
  • Gabriela Mellado-Sánchez Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Unidad de Desarrollo e Investigación en Bioterapéuticos (UDIBI), CDMX, México https://orcid.org/0000-0002-8299-5958
  • Sonia Mayra Pérez-Tapia Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Unidad de Desarrollo e Investigación en Bioterapéuticos (UDIBI), CDMX, México

DOI:

https://doi.org/10.36105/psrua.2024v4n8.02

Palabras clave:

COVID-19, genética humana, variantes genéticas, población mestiza

Resumen

Introducción: Las variantes genéticas asociadas a la COVID-19 son indicadoras de genes causales y potenciales blancos terapéuticos. Desafortunadamente, la mayoría de estos estudios se han realizado en individuos de ancestría europea y desconocemos la presencia de éstas en otras poblaciones. Objetivo: Identificar y confirmar la frecuencia alélica de variantes relacionadas con la COVID-19 en población mexicana mestiza en los genes ABO, CCR2, CCR9, CXCR6, DPP9, FYCO1, IL10RB/IFNAR2, LZTFL1, OAS1, OAS2, OAS3, SLC6A20, TYK2, and XCR1. Métodos: El ADN de 106 pacientes y 2677 individuos sin infección previa y al momento de la entrevista fueron genotipados mediante microarreglo e imputación. Se determinó la frecuencia alélica y ésta se comparó  entre pacientes versus la población general. Resultados: Se confirmaron diferencias en la frecuencia alélica para las variantes ya reportadas, ABO rs657152, DPP9 rs2109069, LZTFL1 rs11385942, OAS1 rs10774671, OAS1 rs2660, OAS2 rs1293767, y OAS3 rs1859330 p<0.03. También reportamos más de 100 variantes con diferencias en la frecuencia alélica entre pacientes y la población general (p-value <10-2), se determinó el impacto funcional in-silico de éstas identificando 4 variantes con un impacto alto en ABO, OAS1/2 and FYCO1. Conclusiones: Se confirman diferencias en la frecuencia alélica entre pacientes con COVID-19 y la población general en mestizos mexicanos, para genes previamente asociados con COVID-19, validando estudios previos, y fomentando el desarrollo de metaanálisis que validen y complementen la información genética relacionada con la infección y severidad a la COVID-19.

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Vol. 4 Núm. 8

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2024-12-20

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Gonzalez-Covarrubiasa, V., Cruz-Jaramilllo, J. L., García‐Muñoz W., Anzures-Cortés, L., Haddad-Talancón, L., Sánchez-García, S., Jiménez Martínez, M. del C., Pérez Barragáne, E., Koepsell, D., Nieto-Patlán, A., Martínez-Ezquerro, J. D., Rubio-Carrascoa, K., Vara Gama, N., del Bosque-Plata, L., Rodríguez-Dorantes, M., Mellado-Sánchez, G., & Pérez-Tapia, S. M. (2024). COVID-19 host-genetics: Known and novel variants in an admixed population. Proceedings of Scientific Research Universidad Anáhuac. Multidisciplinary Journal of Healthcare, 4(8), 13–74. https://doi.org/10.36105/psrua.2024v4n8.02

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Vol. 4 Núm. 8 (2024): Proceedings of Scientific Research Universidad Anáhuac

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Derechos de autor 2024 Vanessa Gonzalez-Covarrubiasa, José Luis Cruz-Jaramilllo, Willebaldo García‐Muñoz, Lourdes Anzures-Cortés, Lorenza Haddad-Talancón, Sergio Sánchez-García, María del Carmen Jiménez Martínez, Edgar Pérez Barragáne, David Koepsell, Alejandro Nieto-Patlán, José Darío Martínez-Ezquerro, Kenneth Rubio-Carrascoa, Nancy Vara Gama, Laura del Bosque-Plata, Mauricio Rodríguez-Dorantes, Gabriela Mellado-Sánchez, Sonia Mayra Pérez-Tapia

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