AIDS-related disseminated Kaposi Sarcoma: a case report

Authors

  • Samanta Ruiz Universidad Anáhuac México https://orcid.org/0000-0001-5080-5059
  • Juan José Díaz-Vintimilla Instituto Nacional de Neurología y Neurocirugía “Manuel Velasco Suárez” https://orcid.org/0000-0002-2985-1883
  • Maximiliano Trevilla-Viveros Hospital General de México “Dr. Eduardo Liceaga”
  • Rogelio Zapata-Arenas Hospital General de México “Dr. Eduardo Liceaga” https://orcid.org/0000-0003-4715-5643
  • Tamara Monserrat Mejia-Alcantara Universidad Autónoma de Guadalajara

DOI:

https://doi.org/10.36105/psrua.2022v2n4.03

Keywords:

Kaposi sarcoma, acquired immunodeficiency syndrome, human herpesvirus 8, human immunodeficiency virus

Abstract

Kaposi sarcoma (KS) is the most common malignant tumor in HIV-infected individuals. Although its most common form consists of skin and mucosal lesions, it can also present itself in a disseminated way affecting the gastrointestinal tract, lungs and eye structures. We present the case of a 27-year-old male patient with HIV infection and disseminated Kaposi sarcoma. Disseminated KS is an uncommon form of the disease. Therefore, it is important to take this into account, particularly in HIV-infected individuals with characteristic cutaneous lesions.

Downloads

Download data is not yet available.

PLUMX metrics

References

Fardin RB, Leite LAC, Bezerra LMDS, Alves PMP, Dos Santos LL, Salvá M de A, et al. Fatal disseminated Kaposi’s sarcoma in two patients with human immunodeficiency virus (HIV) infection. Am J Case Rep. 2018;19:868-74. https://doi.org/10.12659/AJCR.910004

Tang ASO, Teh YC, Chea CY, Yeo ST, Chua HH. Disseminated AIDS-related Kaposi’s sarcoma. Oxf Med Case Reports. 2018;2018:omy107. https://doi.org/10.1093/omcr/omy107

Sousa Neves F, Braga J, Cardoso da Costa J, Sequeira J, Prazeres S. Kaposi’s sarcoma of the conjunctiva and the eyelid leads to the diagnosis of human immunodeficiency virus infection: a case report. BMC Cancer. 2018;18. https://doi.org/10.1186/s12885-018-4611-3

Jin C, Minhas H, Kaur A, Kodali S, Gotlieb V. A case of Ocular Kaposi’s sarcoma successfully treated with highly active antiretroviral therapy (HAART) combined with docetaxel. Am J Case Rep. 2018;19:1074-7. https://doi.org/10.12659/AJCR.910374

Yang J, Yin X-F, Li Y-P, Zhou S-Y. Case report of ocular Kaposi’s sarcoma. BMC Ophthalmol. 2017;17. https://doi.org/10.1186/s12886-017-0525-0

Ruocco E, Ruocco V, Tornesello ML, Gambardella A, Wolf R, Buonaguro FM. Kaposi’s sarcoma: etiology and pathogenesis, inducing factors, causal associations, and treatments: facts and controversies. Clin Dermatol. 2013;31:413-22. https://doi.org/0.1016/j.clindermatol.2013.01.008

Jary A, Veyri M, Gothland A, Leducq V, Calvez V, Marcelin A-G. Kaposi’s sarcoma-associated Herpesvirus, the etiological agent of all epidemiological forms of Kaposi’s sarcoma. Cancers (Basel). 2021;13:6208. https://doi.org/10.3390/cancers13246208

Gutierrez IV, Sarkar P, Rossetto CC. Kaposi’s sarcoma-associated Herpesvirus processivity factor, ORF59, binds to canonical and linker histones, and its carboxy terminus is dispensable for viral DNA synthesis. J Virol. 2021;95. https://doi.org/10.1128/JVI.02169-20

Rossetto JD, Molles S, Gracitelli CPB. Extensive bulbar conjunctival Kaposi’s sarcoma as initial symptom of human immunodeficiency virus. Arq Bras Oftalmol. 2019;82:429-31. https://doi.org/10.5935/0004-2749.20190083

Kaposi. Idiopathisches multiples Pigmentsarkom der Haut. Arch Derm Res. 1872;4:265-73. https://doi.org/10.4067/S0034-98872007000900011

Friedman-Kien AE. Disseminated Kaposi’s sarcoma in homosexual men. Ann Intern Med. 1982;96:693. https://doi.org/10.7326/0003-4819-96-6-693

Beral V, Peterman TA, Berkelman RL, Jaffe HW. Kaposi’s sarcoma among persons with AIDS: a sexually transmitted infection? Lancet. 1990;335:123-8. https://doi.org/10.1016/0140-6736(90)90001-l

Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science. 1994;266:1865-9. https://doi.org/10.1126/science.7997879

Friedman-Kien AE, Saltzman BR. Clinical manifestations of classical, endemic African, and epidemic AIDS-associated Kaposi’s sarcoma. J Am Acad Dermatol. 1990;22:1237-50. https://doi.org/10.1016/0190-9622(90)70169-i

Rusu-Zota G, Manole OM, Galeș C, Porumb-Andrese E, Obadă O, Mocanu CV. Kaposi sarcoma, a trifecta of pathogenic mechanisms. Diagnostics (Basel). 2022;12:1242. https://doi.org/10.3390/diagnostics12051242

Venkateswaran N, Ramos JC, Cohen AK, Alvarez OP, Cohen NK, Galor A, et al. Spotlight on ocular Kaposi’s sarcoma: an update on the presentation, diagnosis, and management options. Expert Rev Ophthalmol. 2021;16:477-89. https://doi.org/10.1080/17469899.2021.1962294

Lin IF, Lin JN, Tsai TH, Hsu CT, Wu YY, Lai CH. Coexistence of disseminated Kaposi sarcoma and multicentric Castleman disease in an HIV-infected patient under viral suppression. Int J STD AIDS. 2021;32:286-9. https://doi.org/10.1177/0956462420968385

Chang KM, Hsieh SL, Harris CA. Disseminated Kaposi sarcoma with cytokine release in an AIDS patient. J Microbiol Immunol Infect. 2022;55:344-6. https://doi.org/10.1016/j.jmii.2021.03.019

Cesarman E, Damania B, Krown SE, Martin J, Bower M, Whitby D. Kaposi sarcoma. Nat Rev Dis Primers. 2019;5-9. https://doi.org/10.1038/s41572-019-0060-9

Downloads

Published

2022-10-10

How to Cite

Ruiz, S. ., Díaz-Vintimilla, J. J. ., Trevilla-Viveros, M. ., Zapata-Arenas, R. ., & Mejia-Alcantara, T. M. (2022). AIDS-related disseminated Kaposi Sarcoma: a case report. Proceedings of Scientific Research Universidad Anáhuac. Multidisciplinary Journal of Healthcare, 2(4), 23–28. https://doi.org/10.36105/psrua.2022v2n4.03