Effect of treatment with probiotics in the reduction of altered levels of the lipid profile in humans and rats: a systematic review

Authors

  • Arturo Martínez Colón Universidad Anáhuac México, Facultad de Ciencias de la Salud, Estado de México https://orcid.org/0009-0004-3240-4162
  • Marcos Meneses Mayo Universidad Anáhuac México, Facultad de Ciencias de la Salud, Estado de México
  • Leticia Lillo Ahuacatitan Universidad Anáhuac México, Facultad de Ciencias de la Salud, Estado de México https://orcid.org/0009-0001-3387-6071

DOI:

https://doi.org/10.36105/psrua.2023v3n6.02

Keywords:

probiotics, lipid-lowering, children, adults, rats, lipid profile

Abstract

Introduction: Evidence suggests that the use of probiotics can prevent or help in the treatment of diseases such as obesity, acute infectious diarrhea, irritable bowel syndrome, liver problems, and the correction of hyperlipidemia, whether of total cholesterol, c-HDL, c-LDL or triglycerides. Probiotic strains have been studied that with various mechanisms can decrease lipid levels in children, adults and rats. Objective: To demonstrate the lipid-lowering effect of some probiotic strains tested in humans and rats, compiling research that supports it. Methods: A search was carried out for articles with a year of publication between 2013 and 2023, experimental, observational and cohort studies published in English, full text available and analysis of the decrease in some lipid profile marker due to the use of probiotics. The MESH terms and the Boolean operators used for the search were “probiotics, lipid-lowering, children; Adults; rats and lipid profile”. Data sources: the databases used were PubMed, Google Scholar, Elsevier, Clinical Key, and ScienceDirect. Results: Of 2150 articles, 30 were included. After the analysis of the selected articles, the results reveal that probiotics have a beneficial effect on the lipid profile by 25,01%. Total cholesterol level was reduced by 16,65%, c-LDL 32,02% and c-HDL was raised by 21,71%. Conclusion: Supplementation with specific strains of probiotics has a lipid-lowering effect, especially it reduces hypercholesterolemia through various mechanisms, but more studies are required to determine the dosage and treatment time.

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References

Candás EB, Pocoví MM, Romero RC, Vella RJC, Esteban SM, Castro CMJ, Rodríguez GE, Arrobas VT, Calmarza P, Puzo FJ. Estrategia para el diagnóstico de las dislipidemias. Revista del Laboratorio Clínico.2019;12(4):21-33ISS.H https://doi.org/10.1016/j.labcli.2019.03.001

Encuesta Nacional de Salud y Nutrición 2020 sobre Covid-19. Instituto Nacional de Salud Pública. 2021. https://ensanut.insp.mx/encuestas/ensanutcontinua2020/doctos/informes/ensanutCovid19ResultadosNacionales.pdf

Sampson UK, Fazio S, Linton MF. Residual cardiovascular risk despite optimal LDL cholesterol reduction with statins: the evidence, etiology, and therapeutic challenges. Curr Atheroscler Rep. 2012 Feb;14(1):1-10. http://dx.doi.org/10.1007/s11883-011-0219-7

Schade DS, Shey L, Eaton RP. Cholesterol Review: A Metabolically Important Molecule. Endocr Pract. 2020 Dec;26(12):1514-1523. https://doi.org/10.4158/EP-2020-0347

Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, Chapman MJ, De Backer GG, Delgado V, Ference BA, Graham IM, Halliday A, Landmesser U, Mihaylova B, Pedersen TR, Riccardi G, Richter DJ, Sabatine MS, Taskinen MR, Tokgozoglu L, Wiklund. ESC Scientific Document Group, 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS). European Heart Journal. 2020;41(1):111–188. https://doi.org/10.1093/eurheartj/ehz455

Ibarretxe D, Masana L. Triglyceride metabolism and classification of hypertriglyceridemias. Unitat de Medicina Vascular i Metabolisme. Hospital Universitari Sant Joan,Reus, Tarragona, España. 2021;33(2):1-6. http://doi.org/10.1016/j.arteri.2021.02.004

Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC, Sperling L, Virani SS, Yeboah J. AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Journal of the American College of Cardiology. 2018; (73)24: 3168-3209. https://doi.org/10.1016/j.jacc.2018.11.002

Yadav M, Verma MK, Chauhan NS. A review of metabolic potential of human gut microbiome in human nutrition. Archives of microbiology. 2018;200(2):203-17. http://doi.org/10.1007/s00203-017-1459-x

Ste Lye HS, Rahmat-Ali GR, Liong MT. Mechanisms of colesterol removal by lactobacilli under conditions that mimic the human gastrointestinal tract. Int Dairy J. 2010; 3:169-175. http://doi.org/10.1016/j.idairyj.2009.10.003

TSai CC, Pei-Pei H, You-Miin Z, Zi-yi W, Hui-Ching H. Cholesterol-Lowering potentials of lactic acid bacteria based on bilesalt hydrolase activity and effect of potent strains on colesterol metabolismin vitroand in vivo. Sci World. 2014: 1-10. https://doi.org/10.1155/2014/690752

Choi SB, Lew LC, Yeo SK, Nair Parvathy S, Liong MT. Probiotics and the BSH-related cholesterol lowering mechanism: a Jekyll and Hyde scenario. Crit Rev Biotechnol. 2015;35(3):392-401. https://doi.org/10.3109/07388551.2014.889077

Tzab HLA, Macswiney GMC. Roedores ¿Plagas indeseables o animales útiles? Biodiversitas. CONABIO. 2014;115;12-16. https://www.uv.mx/personal/cmacswiney/files/2010/10/Tzab-y-MacSwiney_2014.pdf

Ranadheera RDCS, Baines SK, Adams MC. Importance of food in probiotic efficacy. Food Research International. 2010;43(1), 1-7. https://doi.org/10.1016/j.foodres.2009.09.009

Romero-Fernández W, Batista-Castro Z, De Lucca M, Ruano A, García-Barceló M, Rivera-Cervantes M, García-Rodríguez J, Sánchez-Mateos S. El 1, 2, 3 de la experimentación con animales de laboratorio. Rev Peru Med Exp Salud Publica. 2016;33(2):288-99. https://doi.org/10.17843/rpmesp.2016.332.2169

MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. La declaración PRISMA 2020: una guía actualizada para informar revisiones sistemáticas. BMJ2021;372:n71. https://doi.org/10.1136/bmj.n71

Karyana IPG, Apsari NL, Artana IWD, Suarta IK, Yantie PVK, Nesa NNM, Putra IGNS, Soetjiningsih. The efficacy of probiotics supplementation on the lipid profiles of obese adolescents: a randomized trial. Bali Medical Journal. 2022;11(1): 540-544. https://doi.org/10.15562/bmj.v11i1.3163

Fortes PM, Teles Filho RV, Azevêdo LHS, Queiroz VCJ, Costa PSSD. Inflammatory cytokines and lipid profile in children and adolescents with nephrotic syndrome receiving L. Plantarum: a randomized, controlled feasibility trial. Rev Assoc Med Bras (1992). 2020 Nov;66(11):1487-1492. https://doi.org/10.1590/1806-9282.66.11.1487

Guardamagna O, Amaretti A, Puddu PE, Raimondi S, Abello F, Cagliero P, Rossi M. Bifidobacteria supplementation: effects on plasma lipid profiles in dyslipidemic children. Nutrition. 2014 Jul-Aug;30(7-8):831-6. https://doi.org/10.1016/j.nut.2014.01.014

AkbariRad M, Shariatmaghani SS, Razavi BM, Majd HM, Shakhsemampour Z, Sarabi M, Jafari M, Azarkar S, Ghalibaf AM, Khorasani ZM. Probiotics for glycemic and lipid profile control of the pre-diabetic patients: a randomized, double-blinded, placebo-controlled clinical trial study. Diabetol Metab Syndr. 2023 Apr 10;15(1):71. https://doi.org/10.1186/s13098-023-01050-9

Wang S, Ren H, Zhong H, Zhao X, Li C, Ma J, Gu X, Xue Y, Huang S, Yang J, Chen L, Chen G, Qu S, Liang J, Qin L, Huang Q, Peng Y, Li Q, Wang X, Zou Y, Shi Z, Li X, Li T, Yang H, Lai S, Xu G, Li J, Zhang Y, Gu Y, Wang W. Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study. Gut Microbes. 2022 Jan-Dec;14(1):2003176. https://doi.org/10.1080/19490976.2021.2003176

Guerrero-Bonmatty R, Gil-Fernández G, Rodríguez-Velasco FJ, Espadaler-Mazo J. A Combination of Lactoplantibacillus plantarum Strains CECT7527, CECT7528, and CECT7529 Plus Monacolin K Reduces Blood Cholesterol: Results from a Randomized, Double-Blind, Placebo-Controlled Study. Nutrients 2021; 13, 1206. https://doi.org/10.3390/nu13041206

Trotter RE, Vazquez AR, Grubb DS, Freedman KE, Grabos LE, Jones S, Gentile CL, Melby CL, Johnson SA, Weir TL. Bacillus subtilis DE111 intake may improve blood lipids and endothelial function in healthy adults. Benef Microbes. 2020 Nov 15;11(7):621-630. https://doi.org/10.3920/BM2020.0039

Ruscica M, Pavanello C, Gandini S, Macchi C, Botta M, Dall'Orto D, Del Puppo M, Bertolotti M, Bosisio R, Mombelli G, Sirtori CR, Calabresi L, Magni P. Correction to: Nutraceutical approach for the management of cardiovascular risk - a combination containing the probiotic Bifidobacterium longum BB536 and red yeast rice extract: results from a randomized, double-blind, placebo-controlled study. Nutr J. 2019 Sep 9;18(1):54. https://doi.org/10.1186/s12937-019-0438-2

Ahmadian F, Razmpoosh E, Ejtahed HS, Javadi M, Mirmiran P, Azizi F. Effects of probiotic supplementation on major cardiovascular-related parameters in patients with type-2 diabetes mellitus: a secondary-data analysis of a randomized double-blind controlled trial. Diabetol Metab Syndr. 2022 Apr 13;14(1):52. https://doi.org/10.1186/s13098-022-00822-z

Costabile A, Buttarazzi I, Kolida S, Quercia S, Baldini J, Swann JR, Brigidi P, Gibson GR. An in vivo assessment of the cholesterol-lowering efficacy of Lactobacillus plantarum ECGC 13110402 in normal to mildly hypercholesterolaemic adults. PLoS One. 2017 Dec 11;12(12): e0187964. https://doi.org/10.1371/journal.pone.0187964

Fuentes MC, Lajo T, Carrión JM, Cuñé J. A randomized clinical trial evaluating a proprietary mixture of Lactobacillus plantarum strains for lowering cholesterol 1. Mediterranean Journal of Nutrition and Metabolism. 2016;9(2):125-35. http://doi.10.3233/MNM-160065

Kullisaar T, Zilmer K, Salum T, Rehema A, Zilmer M. El uso del suplemento probiótico L. fermentum ME-3 que contiene Reg'Activ Cholesterol durante 4 semanas tiene una influencia positiva en los perfiles de lipoproteínas en sangre y las citoquinas inflamatorias: un estudio preliminar abierto. Diario de Nutrición. 2016;15: 93. https://doi.org/10.1186/s12937-016-0213-6

Rajkumar H, Mahmood N, Kumar M, Varikuti SR, Challa HR, Myakala SP. Effect of probiotic (VSL#3) and omega-3 on lipid profile, insulin sensitivity, inflammatory markers, and gut colonization in overweight adults: a randomized, controlled trial. Mediators Inflamm. 2014; 2014:348959. https://doi.org/10.1155/2014/348959

Nabavi S, Rafraf M, Somi MH, Homayouni-Rad A, Asghari-Jafarabadi M. Effects of probiotic yogurt consumption on metabolic factors in individuals with nonalcoholic fatty liver disease. J Dairy Sci. 2014 Dec;97(12):7386-93. https://doi.org/10.3168/jds.2014-8500

Fuentes, M., Lajo, T., Carrión, J., & Cuñé, J. (2013). Eficacia reductora del colesterol de Lactobacillus plantarum CECT 7527, 7528 y 7529 en adultos hipercolesterolémicos. Revista británica de nutrición, 109 (10),1866-1872. https://doi.org/10.1017/S000711451200373X

Zafar H, Ain NU, Alshammari A, Alghamdi S, Raja H, Ali A, Siddique A, Tahir SD, Akbar S, Arif M, Alharbi M, Rahman A. Lacticaseibacillus rhamnosus FM9 and Limosilactobacillus fermentum Y57 Are as Effective as Statins at Improving Blood Lipid Profile in High Cholesterol, High-Fat Diet Model in Male Wistar Rats. Nutrients. 2022 Apr 15;14(8):1654. https://doi.org/10.3390/nu14081654

Munir A, Javed GA, Javed S, Arshad N. Levilactobacillus brevis from carnivores can ameliorate hypercholesterolemia: In vitro and in vivo mechanistic evidence. Journal of Applied Microbiology. 2022 sep1;133(3):1725-1742. https://doi.org/10.1111/jam.15678

Fossi BT, Ekabe DE, Toukam LL, Tatsilong Pambou HO, Gagneux-Brunon A, Nkenfou Nguefeu C, Bongue B. Probiotic lactic acid bacteria isolated from traditional cameroonian palm wine and corn beer exhibiting cholesterol lowering activity. Heliyon. 2022 Nov 17;8(11): e11708. https://doi.org/10.1016/j.heliyon.2022.e11708

Abdelshafy, A. M., El‐Naggar, E. A., & Kenawi, M. N. (2022). Moringa leaves for improving the health benefits of quinoa fermented by probiotics. Food Bioengineering,1–12. https://doi.org/10.1002/fbe2.12035

Asad F, Anwar H, Yassine HM, Ullah MI, Rahman A, Kamran Z, Sohail MU. White Button Mushroom, Agaricus bisporus (Agaricomycetes), and a Probiotics Mixture Supplementation Correct Dyslipidemia without Influencing the Colon Microbiome Profile in Hypercholesterolemic Rats. Int J Med Mushrooms. 2020;22(3):235-244. https://www.dl.begellhouse.com/journals/708ae68d64b17c52,3f1ff42710c84eff,750bcf123b32c8f8.html

Wa Y, Yin B, He Y, Xi W, Huang Y, Wang C, Guo F and Gu R (2019) Effects of Single Probiotic and Combined Probiotic-Fermented Milk on Lipid Metabolism in Hyperlipidemic Rats. Front. Microbiol. 10:1312. https://doi.org/10.3389/fmicb.2019.01312

Nocianitri, K.A., 2 Antara, N.S., 1 Sugitha, I. M., 3 Sukrama, I. D.M., 4,6Ramona, Y. and 5,6*Sujaya, I. N. The effect of two Lactobacillus rhamnosus strains on the blood lipid profile of rats fed with high fat containing diet. International Food Research Journal. 2017.24(2):795-802. https://doi.org/10.1155%2F2013%2F135142

Chuan Li, Shao-Ping Nie, Qiao Ding, Ke-Xue Zhu, Zhi-Jun Wang, Tao Xiong, Joshua Gong, Ming-Yong Xie. Cholesterol-lowering effect of Lactobacillus plantarum NCU116 in a hyperlipidaemic rat model. Journal of Functional Foods. 2014;(8)340-347. https://doi.org/10.1016/j.jff.2014.03.031

Park DY, Ahn YT, Park SH, Huh CS, Yoo SR, Yu R, Sung MK, McGregor RA, Choi MS. Supplementation of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 in diet-induced obese mice is associated with gut microbial changes and reduction in obesity. PLoS One. 2013;8(3):e59470. https://doi.org/10.1371/journal.pone.0059470

Salaj R, Stofilová J, Soltesová A, Hertelyová Z, Hijová E, Bertková I, Strojný L, Kružliak P, Bomba A. The effects of two Lactobacillus plantarum strains on rat lipid metabolism receiving a high fat diet. ScientificWorldJournal. 2013 Dec 29; 2013:135142. https://doi.org/10.1155/2013/135142

Mohania D, Kansal VK, Shah D, Nagpal R, Kumar M, Gautam SK, Singh B, Behare PV. Therapeutic effect of probiotic dahi on plasma, aortic, and hepatic lipid profile of hypercholesterolemic rats. J Cardiovasc Pharmacol Ther. 2013 Sep;18(5):490-7. https://doi.org/10.1177/1074248413487431

Yoo SR, Kim YJ, Park DY, Jung UJ, Jeon SM, Ahn YT, Huh CS, McGregor R, Choi MS. Probiotics L. plantarum and L. curvatus in combination alter hepatic lipid metabolism and suppress diet-induced obesity. Obesity (Silver Spring). 2013 Dec;21(12):2571-8. https://doi.org/10.1002/oby.20428

Kumar M, Rakesh S, Nagpal R, Hemalatha R, Ramakrishna A, Sudarshan V, Ramagoni R, Shujauddin M, Verma V, Kumar A, Tiwari A, Singh B, Kumar R. Probiotic Lactobacillus rhamnosus GG and Aloe vera gel improve lipid profiles in hypercholesterolemic rats. Nutrition. 2013 Mar;29(3):574-9. https://doi.org/10.1016/j.nut.2012.09.006

Huang Y, Wang X, Wang J, Wu F, Sui Y, Yang L, Wang Z. Lactobacillus plantarum strains as potential probiotic cultures with cholesterol-lowering activity. Journal of dairy science. 2013 May 18;96(5)2746-2753. https://doi.org/10.3168/jds.2012-6123

Park DY, Ahn YT, Huh CS, McGregor RA, Choi MS. Dual probiotic strains suppress high fructose-induced metabolic syndrome. World J Gastroenterol. 2013 Jan 14;19(2):274-83. http://doi.10.3748/wjg.v19.i2.274

Fu J, Bonder MJ, Cenit MC, Tigchelaar EF, Maatman A, Dekens JA, Brandsma E, Marczynska J, Imhann F, Weersma RK, Franke L, Poon TW, Xavier RJ, Gevers D, Hofker MH, Wijmenga C, Zhernakova A. The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids. Circ Res. 2015 Oct 9;117(9):817-24. https://doi.org/10.1161/CIRCRESAHA.115.306807

C. Hill, F. Guarner, G. Reid, G.R. Gibson, D.J. Merenstein, B. Pot, L. Morelli, R.B. Canani, H.J. Flint, S. Salminen, P.C. Calder, M.E. Sanders. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol., 11 (2014), pp. 506-514. https://doi.org/10.1038/nrgastro.2014.66

Hendijani F, Akbari V. Probiotic supplementation for management of cardiovascular risk factors in adults with type II diabetes: A systematic review and meta-analysis. Clin Nutr. 2018 Apr;37(2):532-541. https://doi.org/10.1016/j.clnu.2017.02.015

Dong JY, Szeto IM, Makinen K, Gao Q, Wang J, Qin LQ, Zhao Y. Effect of probiotic fermented milk on blood pressure: a meta-analysis of randomised controlled trials. Br J Nutr. 2013 Oct;110(7):1188-94. http://doi.10.1017/S0007114513001712

Wang L, Guo MJ, Gao Q, Yang JF, Yang L, Pang XL, Jiang XJ. The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials. Medicine.2018 Feb;97(5): e9679. http://doi.10.1097/MD.0000000000009679

Hu YM, Zhou F, Yuan Y, Xu YC. Effects of probiotics supplement in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials. Med Clin. 2017 Apr 21;148(8):362-370. English, Spanish. https://doi.org/10.1016/j.medcli.2016.11.036

Sharma S, Kurpad AV, Puri S. Potential of probiotics in hypercholesterolemia: A meta-analysis. Indian J Public Health. 2016 Oct-Dec;60(4):280-286 http://doi.10.4103/0019-557X.195859

Shimizu M, Hashiguchi M, Shiga T, Tamura HO, Mochizuki M. Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals. PLoS One. 2015 Oct 16;10(10): e0139795. https://doi.org/10.1371/journal.pone.0139795

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2023-12-31 — Updated on 2024-02-27

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Martínez Colón, A. ., Meneses Mayo, M. ., & Lillo Ahuacatitan, L. . (2024). Effect of treatment with probiotics in the reduction of altered levels of the lipid profile in humans and rats: a systematic review. Proceedings of Scientific Research Universidad Anáhuac. Multidisciplinary Journal of Healthcare, 3(6), 14–31. https://doi.org/10.36105/psrua.2023v3n6.02 (Original work published December 31, 2023)